Plasma Peak and Trough Gentamicin Concentrations in Hospitalized Horses Receiving Intravenously Administered Gentamicin
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چکیده
منابع مشابه
Plasma Peak and Trough Gentamicin Concentrations in Hospitalized Horses Receiving Intravenously Administered Gentamicin
BACKGROUND Gentamicin is an aminoglycoside antimicrobial commonly used in horses at 6.6 mg/kg IV once daily. Therapeutic drug monitoring (TDM) can confirm desired peak concentration is reached for common bacterial isolates, and detect toxicosis associated with high trough values. OBJECTIVES Determine the relationship between gentamicin dose and plasma concentration in hospitalized horses, and...
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BACKGROUND Monitoring plasma gentamicin concentrations in neonates 24 hours after a once daily dose (4 mg/kg) often necessitates additional blood sampling. In adults a nomogram has been developed enabling evaluation of gentamicin doses by sampling concentrations with other blood tests, 4-16 hours after administration. We attempted to develop a similar nomogram for neonates. METHODS In additio...
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The pharmacokinetics of intratracheally instilled and intravenously injected gentamicin were compared in the rat and analyzed by a one-compartment open model. The maximum concentration of gentamicin in plasma occurred within 10 min after intratracheal instillation. Considerable amounts of gentamicin were absorbed from lungs after intratracheal instillation, as shown by its concentrations in pla...
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The combination of low sernmii content and low specific activity tracer material has presented a difficult technical barrier to the study of the plasma disappearance of tracer amounts of vitamin BI,2 Three groups (1-3) have studied the rate of plasma disappearance of intravenous (loses ranging fromi 0.5 to 4.0 jg. These (loses were not and could not be considere(l to be of tracer mlagnitu(le si...
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BACKGROUND/AIMS To study the intravitreal antibiotic concentrations and the efficacy of an intravitreal dosing regimen to treat patients with postoperative bacterial endophthalmitis. This regimen, based on pharmacokinetic/pharmacodynamic considerations, relies on a repeat antibiotic injection of a lower dose than is generally used. METHODS In consecutive patients with suspected postoperative ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2015
ISSN: 0891-6640
DOI: 10.1111/jvim.13626